ALS Alert mastheadALS Alert mastheadWinter 2002 - Science. Scope. Speed

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In This Issue:

Celebrex: Let the Trials Begin
It’s good for arthritis, it’s under study for Alzheimer’s, and last month, national trials got under way exploring the anti-inflammation drug Celebrex as a possible ALS therapy. At the Center for ALS Research and 24 other sites, volunteers in early stages of the disease have begun receiving daily high doses.

Sponging Up Glutamate? Good Idea
A new study by Center scientist Margaret Sutherland, Ph.D., not only shores up a long-held idea on a major source of cell damage in ALS but also shows something can be done to fix it, at least in mice.

An Eye on the Shore
Centerwide stem cell research keeps hopes afloat in its early stages. But so far, every study answers questions that lead to more.

The New Rat Model: Bigger Is Better
A new rat model of the disease that’s far easier to work with and more versatile than earlier mouse models.

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A Friend Indeed:
Orioles Hit Home Runs for ALS

photo - Cal Ripken: his streak helped the Center.  
Cal Ripken: his streak helped the Center.

With the Orioles and ALS research, the connection was serendipity. Everything just fell into place the summer of 1995, when Oriole great Cal Ripken was on the verge of breaking Lou Gehrig’s consecutive-games-played record.

At first, the idea of having the Baltimore team support the search for a cure wasn’t obvious—despite Lou Gehrig’s death from ALS. But one evening, as the rest of the country followed Ripken’s every move, a group of men, including Orioles owner Peter Angelos, settled down to a quiet dinner and planning session in a Baltimore restaurant. When Angelos asked the men to consider a way to mark what was sure to be an historic, record-setting game for the Orioles, his friend Dick McCready leaned forward and suggested “support ALS research.”

McCready has a history of kindness toward medical causes—at Johns Hopkins, for example, he helped found the Grant-a-Wish Foundation to ease the lives of children with life-threatening diseases. He also had another tie: McCready hoped to spare others the experiences his mother had endured as a patient with ALS. She’d gotten good care at Hopkins, but McCready saw that the search for a cure greatly needed funding.

With no time to lose, Angelos set up the Cal Ripken Jr./Lou Gehrig Fund to support ALS research. At Ripken’s historic game in September 1995, the Orioles sold 260 special on-the-field seats, and Cal presented a $2 million check to Hopkins while the crowd cheered.

photo - Center friends take over an Oriole Park skybox.  
Center friends take over an
Oriole Park skybox.

 

Since then, Orioles’ donations have continued to swell and currently have far exceeded the $2 million. The ball club’s help, both in dollars and in services is making a real difference for the Center for ALS Research at Johns Hopkins.

Both Dick McCready, a food broker and successful Baltimore businessman, and Orioles’ Vice Chairman and COO Joe Foss are now on the Center’s board of directors.

Next > Being resourceful
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Special Features:

Vantage point
One of the most satisfying things about directing the Center has been watching the shift in our thinking about the biology of ALS.

On Center: Fund-Raisers’ Bounty Keeps Center on Track
It’s a rare foundation that doesn’t have to depend on fund raising. With the Center for ALS Research, dedicated as it is to a high volume and a rapid turnout of lab results, benefits and such events are crucial. But even for this stepped-up place, the pace has been fast.

Insider’s View
Daniel Drachman, M.D., is a longtime Hopkins neurologist / researcher who specializes in neuromuscular diseases. In this column he answers questions.

From the Clinic
Lora Clawson, M.S.N., C.R.N.P., manages Johns Hopkins’ ALS clinic. She also oversees its clinical trials. In this column she answers typical patients’ questions.

A Friend Indeed: Orioles Hit Home Runs for ALS
With the Orioles and ALS research, the connection was serendipity. Everything just fell into place the summer of 1995, when Oriole great Cal Ripken was on the verge of breaking Lou Gehrig’s consecutive-games-
played record.

Being resourceful
Links to useful information

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