Listed below are the clinical research studies currently underway or in planning stages at the Johns Hopkins ALS Clinic.

Research Studies currently enrolling participants:

A methodology study of muscle biopsy samples from ALS patients to develop assays for Nogo and other biomarkers
Andrea Corse, MD – Principal Investigator
Click here for study information (PDF file)

A Longitudinal Study of Cognition and Behavior in ALS
Chiadi Onyike, MD, MHS – Principal Investigator

A Multicenter Study for the Validation of ALS Biomarkers
Nicholas Maragakis, MD – Principal Investigator
Click here for study information (PDF file)

Dextromethorphan/Quinidine: Study to Assess the Safety and Efficacy of the study drug Dextromethorphan/Quinidine in the Treatment of Pseudobulbar Affect in ALS
Andrea Corse, MD – Principal Investigator
Click here for study information (PDF file)

Electrical impedance myography as an outcome measure in ALS clinical trials
Nicholas Maragakis, MD – Principal Investigator

Quality of Life and Caregiver Burden in ALS
Richard Kimball, MSN/MPH APRN PhD(c) – Principal Investigator
Click here for study information (PDF file)

ENROLLMENT CLOSING Oct 25, 2008 for this study ONLY:
A 2-Part, Randomized, Double-Blind, Safety and Tolerability Study Evaluating KNS-760704 in Patients with Amyotrophic Lateral Sclerosis (ALS)
Jeff Rothstein, MD, PhD – Principal Investigator
Click here for study information (PDF file)

Upcoming trials, not yet enrolling participants:

A Multinational, Multicenter, Randomized, Double‑Blind, Placebo‑ Controlled, Parallel‑Group Study to Assess the Efficacy, Tolerability and Safety of talampanel in Subjects with ALS
Nicholas Maragakis, MD & Jeff Rothstein, MD – Principal Investigators
Planned Start: late 2008

Skin biopsies to generate cell lines for study of ALS
Nicholas Maragakis, MD – Principal Investigator
Planned Start: late 2008

A Multicenter, Double‑Blind, Placebo‑Controlled, Study to Investigate the Safety and Efficacy of Lithium in combination with Riluzole in Volunteers with ALS
Brett Morrison, MD – Principal Investigator
Planned Start: late 2008

A Phase 2 Repeat-Dosing Clinical Trial of SB-509 in Subjects with Amyotrophic Lateral Sclerosis - Sangamo BioSciences, Inc.
Nicholas Maragakis, MD – Principal Investigator
Planned start: early 2009

Safety and Tolerability of the Ketogenic Diet in ALS
Vinay Chaudhry, MD – Principal Investigator
Planned Start: early 2009

Arimoclomol: Phase 2b Study to Investigate the Safety and Efficacy of Arimoclomol in ALS Nicholas Maragakis, MD – Principal Investigator
Planned Start: On CLINICAL HOLD by the FDA until further notice

No Longer Enrolling Participants:

Diaphragm Pacing of Patients with ALS
Nicholas Maragakis, MD – Principal Investigator

Quality of Life in ALS
Andrea Corse, MD – Principal Investigator

Early BiPAP Use in ALS
Noah Lechtzin, MD – Principal Investigator

Validation of Retrospective Generation of ALSFRS-R scores in ALS
Noah Lechtzin, MD – Principal Investigator

DNA Registry in ALS
Nicholas Maragakis, MD – Principal Investigator

For information about these clinical trials, please contact
Lora Clawson, MSN, CRNP
Director of ALS Clinical Services
410-955-8511
lclawson@jhmi.edu

NATIONAL INSTITUTES OF HEALTH
http://www.clinicaltrials.gov/