| Packard Center for ALS Research at Johns Hopkins |
Genetic Studies Find Clues to 'Lou Gehrig's Disease' RiskTwo teams report on role chromosome 9 seems to play in amyotrophic lateral sclerosisBryan Traynor is a Packard Center InvestigatorMONDAY, Aug. 30 (HealthDay News) -- Genetic variations on a specific chromosome appear to play a role in a fatal motor neuron condition known as amyotrophic lateral sclerosis, or Lou Gehrig's disease, two teams of scientists have found. In one study, Bryan Traynor, from the U.S. National Institutes of Health, and an international group of colleagues analyzed the genomes of 405 amyotrophic lateral sclerosis (ALS) patients in Finland and 497 people without the disease ("controls"). The investigators pinpointed genetic variations on chromosome 9 that are linked to increased risk for ALS. In the other study, Ammar Al-Chalabi, from Kings College London, led an international team in examining DNA samples from 599 ALS patients and 4,144 controls in the United Kingdom, and found strong evidence of an association between two genetic variations on chromosome 9 and ALS. | Events
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