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NIH grant funds study on stem cells from ALS patients

February 22, 2010

By Amy Lunday and Christen Brownlee

A two-year $3.7 million stimulus grant from the National Institutes of Health will allow Johns Hopkins neurologist and lead researcher Jeffrey Rothstein to expand on his long-standing research into the nerve- and muscle-wasting disease amyotrophic lateral sclerosis, or ALS.

Using stem cells developed in a laboratory from skin cell samples taken from 20 ALS patients and five control subjects, Rothstein and his colleagues will study the biology and chemistry involved in the development and progression of the disease and will test drugs to intervene in the process. When the two-year program is completed, the cells generated will be available nationwide to other researchers.

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