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Aaron Gitler & Julianne Gross

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Aaron Gitler, PhD & Julianne Grose, PhD

Stanford University (Gitler)
Brigham Young University (Grose)

Characterizing a kinase regulator of ataxin-2 as a therapeutic target for ALS

Mutations in a gene called ataxin-2 are a genetic risk factor for ALS. Therapeutic approaches aimed at lowering the levels of ataxin-2 could be effective in ALS. This collaborative project aims to test a putative kinase regulator of ataxin-2 as a way of reducing levels of ataxin-2.

 

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Steven Finkbeiner

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Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
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