Edor Kabashi, PhD
Functionally characterizing genetic interactions between ATX2 polyQ repeats and TDP-43
Our goal is to identify novel protein partners of mutant TDP-43 and FUS that could contribute to mechanisms associated with motor neuron degeneration using the transgenic zebrafish models we previously developed. Identification of specific protein partners that can selectively induce neurodegeneration has been impeded by the similar toxic profiles of TDP-43 and FUS. The discovery of these partners can shed light to a better understanding of neurodegenerative pathways elicited in ALS and may provide both novel avenues for genetic factors in motor neuron diseases and new targets for therapeutic intervention in ALS patients.