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ALS Research Projects: Grants on the Rise

To date, the Robert Packard Center for ALS Research at Johns Hopkins has awarded 145 research grants and has several new grants pending, at a total of $28 million. Through and invitation-only process, the Center awards ALS research grants throughout the year on a flexible time frame, with the idea that rapid funding fosters innovative ideas.   Listed below is our current research portfolio.

Sami Barmada, MD, PhD
Mechanisms of initiation and progression in ALS

David Borchelt, PhD & Jacob Ayers, PhD
Role of misfolded wild-type SOD1 in cases of sporadic ALS

Steven Finkbeiner, MD, PhD
Human Neuromuscular Models of ALS

Fen-Biao Gao, PhD
iPSC-Derived Motor Neuron Models of ALS with C9ORF72 Repeat Expansion

Aaron Gitler, PhD & James Shorter, PhD
Genetic and biochemical approaches to define mechanisms of RAN translation in C9orf72-associated ALS

Terry Heiman-Patterson, MD
Phenotype modifiers in murine motor neuron disease: studies in the G93AhSOD1 mouse models of ALS

Jean-Pierre Julien, PhD
Single-chain antibodies against TDP-43 RRM1 domain for treatments of ALS

Edor Kabashi, PhD
Functionally characterizing genetic interactions between ATX2 polyQ repeats and TDP-43

Albert La Spada, MD, PhD
Role of senataxin in regulating c9orf72 repeat mediated transcription dysregulation and neurotoxicity in ALS

Gabsang Lee, PhD, DVM & Nicholas Maragakis, MD
Derivation of oculomotor neurons using PHOX2b::GPF reporter ALS-hiPSC lines

Thomas Lloyd, MD, PhD
Axonal transport and retrograde signaling in Drosophila models of c9-ALS

Nicholas Maragakis, MD
Investigating the contributions of astrocyte gap junctions to ALS disease progression

Timothy Miller, MD, PhD
miRNA enriched in ALS-vulnerable motor neurons as therpeutic targets

Mervyn J. Monteiro, PhD
Generation and characterization of ubiquilin-2 transgenic mice models of ALS

Mervyn J. Monteiro, PhD (Project co-funded with ALSA)
Gene profiling to determine the initiator mechanisms involved in disease in a UBQLN2 mouse model of ALS-FTD

Uday Pandey, PhD
Investigating the molecular mechanisms of FUS-related ALS

Leonard Petrucelli, PhD
The role of epigenetic changes and downstream pathological events in c9FTD/ALS

Rita Sattler, PhD
Role of synaptic dysfunction in C9orf72-mediated pathogenesis in patient-derived iPS neurons and in vivo animal models

Shan Sockanathan, PhD
Mechanisms of motor neuron loss in ALS

J. Paul Taylor, MD, PhD
Altered RNA Metabolism in C9ORF72-associated ALS

Jiou Wang, MD, PhD
Using C. elegans to Investigate Molecular Mechanisms of ALS

Philip Wong, PhD
Functional role of the C-terminal prion-like domain of TDP-43

Philip Wong, PhD & Liam Chen, MD, PhD
Targeting TDP-43 Repression of Nonconserved Cryptic Exons in ALS-FTD

Zuoshang Xu, PhD & John Landers, PhD
Modeling ALS in mice based on profilin 1 mutation

Steven Finkbeiner

Our Experts

Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
Meet Our Experts