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Paschalis Kratsios, PhD

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Paschalis Kratsios, PhD

University of Chicago

Molecular mechanisms that maintain motor neuron function throughout life

Amyotrophic lateral sclerosis (ALS) is characterized by defects in the survival or function of specialized neuronal cells called motor neurons. The research in this proposal focuses on identifying the molecular mechanisms that maintain motor neuron function throughout life. The insights gained from this project may provide novel entry points into the etiology, diagnosis or treatment of ALS.

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Steven Finkbeiner

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Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
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