Philip Wong, PhD
Functional role of the C-terminal prion-like domain of TDP-43
While advances has been made towards our understanding the role of an RNA binding protein termed TDP-43 linked to ALS-FTD, the precise function of this protein remains incompletely known. Based on our recent findings, we propose a novel function of TDP-43 that may lead to identification of biomarkers relevant to ALS and offer potential design of therapeutic strategies to attenuate this devastating disease of the elderly.
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Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
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